14.06.2020, 05:12
After oral administration, both components are rapidly absorbed in the digestive tract. Simultaneous ingestion does not affect absorption. T Cmax - 45 min. After oral administration at a dose of 250/125 mg every 8 hours, C max of amoxicillin is 2.18-4.5 μg / ml, clavulanic acid is 0.8-2.2 μg / ml, at a dose of 500/125 mg every 12 hours C max of amoxicillin is 5.09-7.91 μg / ml, clavulanic acid - 1.19-2.41 μg / ml, at a dose of 500/125 mg every 8 hours C max amoxicillin - 4.94-9.46 μg / ml, clavulanic acid - 1.57-3.23 μg / ml, at a dose of 875/125 mg C max amoxicillin - 8.82-14.38 μg / ml, clavulanic acid - 1.21-3.19 μg / ml.
After iv administration in doses of 1000/200 and 500/100 mg C max of amoxicillin - 105.4 and 32.2 μg / ml, respectively, and clavulanic acid - 28.5 and 10.5 μg / ml.
The time to reach a maximum inhibitory concentration of 1 μg / ml for amoxicillin is similar when used after 12 hours and 8 hours in both adults and children.
Plasma protein binding: amoxicillin - 17-20%, clavulanic acid - 22-30%.
Both components in the liver are metabolized: amoxicillin - 10% of the administered dose, clavulanic acid - 50%.
T 1/2 after administration at a dose of 375 and 625 mg - 1 and 1.3 hours for amoxicillin, 1.2 and 0.8 hours for clavulanic acid, respectively. T 1/2 after i / v administration at a dose of 1200 and 600 mg - 0.9 and 1.07 h for amoxicillin, 0.9 and 1.12 h for clavulanic acid, respectively. It is excreted mainly by the kidneys (glomerular filtration and tubular secretion): 50-78 and 25-40% of the administered dose of amoxicillin and clavulanic acid are excreted, respectively, unchanged for the first 6 hours after administration.
Augmentin 1000 mg / 62.5 mg
Immediate Release (HB) Layer
Layer providing gradual release (PV)
No analogues were found for the drug in action
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The active substances have similar pharmacokinetic parameters, which allows them to be used simultaneously. Both compounds are rapidly absorbed from the digestive tract. The bioavailability of amoxicillin exceeds 90%, clavulanate is absorbed by 60-70%.
The maximum concentration of the drug in the blood is achieved on average in 1.5-2 hours, which leads to a rapid distribution of the drug in the tissues and body fluids. Concentration in places of bacterial lesions, purulent contents of abscesses and abscesses, bronchial secretion exceeds the amount of drugs in non-inflamed areas.
Active substances penetrate into all glandular tissues, mucous membranes, exudates, sputum, synovial fluid, muscles, joints and bone tissue. Overcome the placental and blood-brain barriers, excreted in breast milk.
The metabolization of components occurs in the liver, and excretion is carried out by glomerular filtration through the kidneys. A small amount of inactive metabolites is secreted through the lungs and intestines. Substances are eliminated in 5-6 hours. The elimination half-life lengthens in case of impaired renal function. Both substances are almost completely removed during hemodialysis, in small quantities during peritoneal dialysis..
Atrovent is a supportive drug for a number of diseases of the bronchi and lungs. http://ear.emedtv.com/augmentin-es/augmentin-es-overdose.html As a rule, doctors prescribe it with the appearance of bronchodilators in case the patient is diagnosed with: chronic stages of obstructive.
